Editorial Technical Reference

Industrial Bioreactor

This page explains how Industrial Bioreactor is classified within Food Manufacturing. Technical values and manufacturer relationships are research references; confirm the current specification and supplier evidence for each order.

Technical Definition & Core Assembly

Controlled vessel that cultivates microorganisms or cells under regulated temperature, pH, oxygen, and agitation for fermentation-based production.

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Product Specifications

Technical details and manufacturing context for Industrial Bioreactor

Definition
An industrial bioreactor provides the sterile, monitored environment where bacteria, yeast, fungi, or cell cultures convert substrates into products such as enzymes, amino acids, probiotics, alcohol, and biopharmaceutical intermediates. Stirred-tank designs from bench scale to several hundred cubic meters dominate, built in electropolished stainless steel 316L with jacketed temperature control, sterilizable-in-place piping, spargers for aeration, and instrumentation for pH, dissolved oxygen, and foam. Vessel geometry, oxygen transfer rate, and cleanability determine which processes a given fermenter can run economically. This directory entry covers stirred-tank bioreactors intended for food manufacturing, with working volumes from 100 to 10,000 liters, agitation speeds from 50 to 500 rpm, temperature control from 5 to 80 °C, pH control from 2 to 12, dissolved oxygen control from 0 to 100%, aeration rates from 0.5 to 2.0 vvm, sterilization temperatures from 121 to 135 °C, material grade 316L (ASTM A240), surface finish ≤0.4 μm Ra (ISO 4287), electrical power from 5 to 50 kW, control voltage 24 V DC ±10% (IEC 61131-2), ingress protection IP54–IP65 (IEC 60529), and weight from 500 to 5000 kg. Materials on file include electropolished 316L vessel, 304 jacket and frame, EPDM or PTFE sanitary seals, borosilicate sight glasses, and sanitary diaphragm valves and sensors. Relevant standards include ASME BPE, EHEDG hygienic design, and GB 150 with SIP rating. These references are for procurement and verification; they do not imply certification of any specific product. Always verify model-specific values and standards with the legal manufacturer or supplier before purchase or installation.
Working Principle
After sterilization-in-place with steam, the vessel receives medium and inoculum; an agitator with Rushton or hydrofoil impellers disperses sparged air while the jacket removes metabolic heat. Probes feed pH, DO, and temperature to a controller that doses acid, base, antifoam, and feed substrate, maintaining setpoints through the batch, fed-batch, or continuous run. The system relies on precise control of agitation, aeration, and temperature to ensure homogeneity and oxygen transfer. Operators must confirm that the vessel's geometry and oxygen transfer rate match the intended process. Maintenance signals include deviations in pH, DO, or temperature control, and fouling of spargers or probes. Failure boundaries are defined by the vessel's pressure rating and material compatibility; exceeding these limits can compromise safety and product quality.
Common Materials
stainless steel 316L electropolished vessel, stainless steel 304 jacket and frame, EPDM or PTFE sanitary seals, borosilicate sight glasses, sanitary diaphragm valves and sensors
Technical Parameters
ParameterTypical rangeNotes & selection driver
Working Volume100–10000 LScalable for pilot to production
Agitation Speed50–500 rpmMaintains homogeneity and oxygen transfer
Temperature Control Range5–80 °CPrecise control for microbial growth
pH Control Range2–12 pHWith acid/base addition
Dissolved Oxygen Control0–100 %Cascade with agitation and aeration
Aeration Rate0.5–2.0 vvmVolume of air per volume of medium per minute
Sterilization Temperature121–135 °CIn-place sterilization (SIP)
Material Grade316LCorrosion-resistant, food-gradeASTM A240
Surface Finish≤0.4 μm RaFor hygienic cleaningISO 4287
Electrical Power5–50 kWDepends on vessel size
Control Voltage24 ±10% V DCFor sensors and PLCIEC 61131-2
Ingress ProtectionIP54–IP65Dust-tight and water-resistantIEC 60529
Weight500–5000 kgIncreases with volume and options

Ranges are indicative industry figures for RFQ preparation, not a supplier commitment. Confirm every value and standard with the legal manufacturer before ordering.

Components / BOM
  • Vessel
    The sterilisable tank that holds medium and culture.
  • Agitator
    Drives the impellers that disperse the sparged air.
  • Impellers
    Rushton or hydrofoil blades that mix the broth and break up bubbles.
  • Sparger
    Introduces the air stream into the broth.
  • Jacket
    Removes the metabolic heat from the vessel.
  • Probes
    Feed pH, dissolved oxygen and temperature back to the controller.
  • Controller
    Doses acid, base, antifoam and feed to hold the setpoints.

Application & selection

Application Fit & Sizing Matrix

Operational Limits
sterility: SIP-rated vessel with 0.2 µm inlet air filtration
volume range: 5 L pilot to 500 m³ industrial
control scope: pH, DO, temperature, foam, feed, pressure
culture types: bacterial, yeast, fungal, cell culture variants
operation modes: batch, fed-batch, continuous

Risk, maintenance & compliance

Reliability & Engineering Risk Analysis

Failure Mode & Root Cause
Batch contamination
Cause: Compromised sterile boundary from pitted welds, worn valve diaphragms, or failed air-filter integrity, letting foreign organisms outgrow the production strain.
Oxygen limitation at peak demand
Cause: Undersized sparger or agitator for the strain's uptake rate, stalling growth and yields despite correct medium and temperature.
Maintenance Indicators
Engineering Tips

Indicative industry ranges for design and RFQ preparation. Confirm the exact figures and applicable standard with the manufacturer before specifying.

Technical documentation
Request current drawings, revision history, and a signed specification sheet.
Manufacturing capability
Verify equipment lists, process limits, capacity, and representative production evidence.
Inspection readiness
Confirm test methods, calibrated equipment, sampling plans, and traceable reports.
Supplier transparency
Check the legal entity, factory address, ownership, certifications, and direct contacts.

CNFX does not score or rank suppliers. Buyers must verify all claims and documents with the legal manufacturer before ordering.

Manufacturers of Industrial Bioreactor

1 company lists this product among what they make. Company figures are quoted from each company's own website; every card states where the relationship came from.

Lehui International Engineering Equipment Co., Ltd.
Ningbo, Zhejiang, CN
Founded 1991
ISO9001 ASME PED UKCA +2
Stated by the company · profile compiled by CNFX from public sources
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Frequently Asked Questions

What is the typical working volume range for this industrial bioreactor?

The directory lists a working volume range of 100 to 10,000 liters, scalable for pilot to production. However, the exact volume depends on the specific model and configuration. Always confirm with the manufacturer or supplier.

Which materials are used in the construction of this bioreactor?

The vessel is made of electropolished stainless steel 316L, with a 304 stainless steel jacket and frame. Seals are EPDM or PTFE, sight glasses are borosilicate, and valves and sensors are sanitary diaphragm type. These materials are food-grade and corrosion-resistant.

What standards are relevant for this bioreactor?

Relevant standards include ASME BPE for bioprocessing equipment, EHEDG hygienic design, and GB 150 for pressure vessels with SIP rating. These are references for procurement and verification; they do not guarantee certification of a specific product.

How is sterilization performed?

Sterilization is performed in-place (SIP) using steam at temperatures from 121 to 135 °C. The system is designed to withstand these conditions. Verify the sterilization cycle and compatibility with your process with the supplier.

Data basis: editorial classification, named public sources where available, and source-reviewed manufacturer records. See the editorial policy.

Data Basis

Editorial classification, named public sources where available, and source-reviewed manufacturer records.

Preliminary Technical Classification
This page supports structured research, RFQ preparation, and supplier evaluation. It does not replace buyer-led supplier qualification, standards review, or technical approval.

Compiled and source-reviewed by the CNFX editorial team. Each manufacturer above links to the page on that company's own website where the product is listed, with the date we checked it. How we source and review · Page last updated 6 September 2026

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