Editorial Technical Reference

Programmable gain amplifier (PGA)

Programmable gain amplifiers · binary and decade gain steps set over SPI, input multiplexers and calibration channels, gain error, offset and drift, gain switching time, rail-to-rail ADC drivers versus high-voltage instrumentation PGAs

A PGA changes voltage gain through digital control so a signal chain can serve different input ranges. Select gain steps, channels and the analog input/output ranges together. The time to change a gain code and the time until the ADC input is settled are different requirements.

Integrated programmable gain amplifiers and programmable-gain instrumentation amplifiers with digital gain control, with or without input multiplexers, used to drive ADCs in data acquisition, metering and industrial I/O. Fixed-gain operational and differential amplifiers (separate product pages), digital potentiometers and complete DAQ modules are outside this page except where compared.

CNFX editorial research · Sources checked October 18, 2026 · 5 sources

Programmable Gain Amplifier (PGA) in a manufacturing environment
Representative product image. Confirm appearance and specifications with the manufacturer.

01

Pick the gain steps and channels

TI's PGA112/PGA113/PGA116/PGA117 data sheet describes zero-drift PGAs with binary gains of 1, 2, 4, 8, 16, 32, 64 and 128 (PGA112, PGA116) or scope gains of 1, 2, 5, 10, 20, 50, 100 and 200 (PGA113, PGA117), a 2-channel (10-pin VSSOP) or 10-channel (20-pin TSSOP) input MUX, a three-pin SPI interface, four internal calibration channels (GND, 0.9 VCAL, 0.1 VCAL and VREF), 200 ns gain switching time, rail-to-rail input and output, and an output optimised for driving capacitive-DAC ADCs. [1] Microchip's MCP6S21/2/6/8 offer 1, 2, 6 or 8 multiplexed inputs and gains of +1, +2, +4, +5, +8, +10, +16 or +32 V/V selected over SPI, on a single 2.5–5.5 V supply, with 2–12 MHz bandwidth marked “typ” and shutdown via the serial interface. [3]

Editorial calculation: assuming an ideal zero-offset, noninverting gain stage, a unipolar 20 mV input and a 0–2.5 V ADC range, 0.020 × 64 = 1.28 V, 0.020 × 128 = 2.56 V and 0.020 × 100 = 2.0 V. The nominal 128 setting exceeds that assumed ADC range. The nominal ratio 128/1 corresponds to 20 log₁₀(128) ≈ 42.14 dB. These are editorial calculations, not manufacturer-published operating measurements or a completed gain selection; allow actual reference level, headroom, offset, gain error and transients before selecting hardware. [1]

Give the supplier the signal ranges per channel, number of channels, gain steps needed (binary or decade), ADC input range and type, supply voltages, interface (SPI, daisy-chain, GPIO), gain error, offset and drift limits, noise, bandwidth and settling time after gain changes, input voltage range and protection, package and temperature range.

02

Check accuracy, drift and input range

Under the PGA112 family’s stated 5 V, 25°C and mid-supply common-mode conditions, offset is ±25 µV in the “TYP” column and ±100 µV maximum. Its −40 to +125°C, 2.5 V common-mode drift entries are 0.35 µV/°C in “TYP” and 1.2 µV/°C maximum; different common-mode and temperature conditions have different entries. Gain error is 0.1% maximum at G ≤ 32 and 0.3% at the higher listed gains, within the stated output range. Its 12 nV/√Hz noise-density entry is in “TYP” at 5 V and above 10 kHz. [1] Microchip’s MCP6S2x headline values are ±1% maximum gain error, ±275 µV maximum offset and 10 nV/√Hz at 10 kHz marked “typ”, with the stated −40 to +85°C specification range. [3] TI’s PGA280 headline input range is ±15.5 V on ±18 V supplies. Its gain-128 offset table gives ±3 µV in “TYP” and ±15 µV maximum under its stated test conditions. It also provides differential output, input switching, overload detection and wire-break test current; check the detailed limits rather than treating its headline CMRR as a guarantee under every condition. [2]

Editorial note: check the total error from gain error and offset at the gain you will actually use, and allow the settling time after each gain change before the ADC samples.

03

Separate a standalone PGA from an MCU analog front end

The standalone TI and Microchip parts leave converter selection outside the PGA; Renesas’s identified MCU integrates its analog front end. [1] [3] [4]

Types include low-voltage rail-to-rail PGAs with integrated MUX for ADC driving, and high-voltage programmable-gain instrumentation amplifiers with differential output and diagnostics for industrial analog input modules. [1] [3] [2]

04

Consider a PGA built into a delta-sigma ADC front end

Renesas’s RX23E-A datasheet Rev.1.30, dated 25 December 2024, describes integrated delta-sigma ADCs and PGA gains from 1 to 128. Its up-to-23-bit effective-resolution headline is at gain 1 and 7.6 SPS, not at every gain and rate. Normal-mode output rates are 7.6–15625 SPS, while low-power mode is 1.9–3906 SPS. The device’s VCC range starts at 1.8 V, but the delta-sigma analog supply AVCC0 is 2.7–5.5 V; the lower analog-supply exception applies only when S12AD operates. Do not carry the MCU VCC minimum over to the delta-sigma PGA front end. [5]

In the cited Renesas electrical table, offset drift at PGA gains 64–128 is 10 nV/°C in “Typ.” and 25 nV/°C maximum. Lower gains have different entries. Gain drift with the PGA enabled and OPCR.DSADLVM = 0 is 1 ppm/°C in “Typ.” and 3 ppm/°C maximum; other modes and supplies have different limits. This replaces an unqualified drift comparison based on a product-page summary. [5]

The Renesas product page identifies an MCU with an analog front end; use its linked datasheet conditions for quantitative selection. Compare noise, effective resolution, reference conditions and settling at the gain and data rate used. [4] [5]

Selection boundaryRX23E-A integrated front endStandalone PGA112 family
Gain1–128 with documented mode conditions. [5]Binary or scope-step part variants. [1]
SupplyVCC and analog AVCC0 have distinct minima. [5]Check both analog and digital supplies. [1]
ConversionOn-chip delta-sigma ADC with gain/rate-specific performance. [5]External ADC and sampling conditions selected separately. [1]

05

Track channel selection, gain and reference paths

The gain code alone does not identify the input channel, reference level or output-settling condition.

FunctionRoleFix in the order
Input MUXSelects a channel. [1] [3]Channel count.
Gain networkResistor ladder sets gain. [3]Gain steps.
Amplifier coreZero-drift or standard. [1] [2]Offset; drift; noise.
SPI interfaceSets gain and channel. [1] [3]Daisy-chain; GPIO.
Calibration channelsSystem calibration. [1]Reference inputs.
DiagnosticsOverload and wire-break checks. [2]Features needed.

06

Specify analog settling separately from gain-code switching

Record the allowed error band, output step and load when asking for settling time.

FieldWhat it means and published valuesAsk the supplier for
Gain stepsExamples: 1–128 binary; 1–200 scope; 1–32. [1] [3]Steps available.
Gain errorPGA112: 0.1% maximum at G ≤ 32 within the stated output window; MCP6S2x headline ±1% maximum. [1] [3]At your gain.
Offset / driftPGA112 table values depend on common-mode voltage and temperature range; use the stated “TYP” and maximum entries. [1]Max values.
Gain switchingPGA112 feature: 200 ns gain switching; analog settling is specified separately by gain, output step and error band. [1]Settling time.
Input rangeExample: ±15.5 V (PGA280). [2]Range and protection.
SupplyExample: 2.5–5.5 V single supply. [3]Rails.

07

Send the signal, ADC and interface data together

Paste it into your enquiry below or into an email to a maker, then replace every bracket.

Signals: [ranges; channels; bandwidth]
Gain: [steps; switching rate]
Accuracy: [gain error; offset; drift; noise]
ADC: [type; input range]
Supply: [rails]
Interface: [SPI; daisy-chain]
Package: [type; temperature]

See manufacturer records Send an enquiry through CNFX

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Buyer questions

What gains do PGAs offer?

Examples: TI's PGA112 offers binary gains 1–128 and the PGA113 scope gains 1–200; Microchip's MCP6S2x offers +1 to +32 V/V. [1] [3]

How fast can a PGA change gain?

The PGA112 family headline gives 200 ns gain switching. This is not an ADC-ready settling guarantee: use the separate gain-, step-, load- and accuracy-dependent settling data. [1]

Can a PGA take industrial ±10 V signals?

TI’s PGA280 headline range is ±15.5 V on ±18 V supplies. Verify the actual common-mode voltage, gain, differential output range and supply conditions for the industrial input; an input-range headline alone is insufficient. [2]

Can the PGA be built into the ADC?

RX23E-A integrates delta-sigma conversion with a PGA. Its datasheet gives gain- and mode-dependent performance; the MCU’s 1.8 V VCC minimum is not the 2.7 V minimum for the delta-sigma analog supply AVCC0. [5]

Sources and what still needs a direct check

Sources checked 2026-10-18. The identified TI and Microchip datasheets describe standalone parts. Renesas’s product page and linked Rev.1.30 datasheet describe an MCU front end with separate analog-supply, gain, data-rate and mode conditions.

  1. Texas Instruments — PGA112/PGA113/PGA116/PGA117 Zero-Drift Programmable Gain Amplifier With Mux data sheet (SBOS424C) ↗ Maker data sheet Return to text ↑
  2. Texas Instruments — PGA280 Zero-Drift, High-Voltage, Programmable Gain Instrumentation Amplifier data sheet (SBOS487B) ↗ Maker data sheet Return to text ↑
  3. Microchip — MCP6S21/2/6/8 Single-Ended, Rail-to-Rail I/O, Low Gain PGA data sheet (DS21117B) ↗ Maker data sheet Return to text ↑
  4. Renesas Electronics — RX23E-A group microcontrollers with analog front end: product page (2026) ↗ Maker product page Return to text ↑
  5. Renesas — RX23E-A Group Datasheet R01DS0330EJ0130, Rev.1.30 (25 December 2024), pp.1, 6, 72–73 ↗ Manufacturer datasheet Return to text ↑

Still to check yourself

  • Pick gain steps for your signal ranges.
  • Check gain error and offset at the used gain.
  • Allow settling after gain changes.
  • Confirm input range and protection.
  • Verify the legal supplier and factory.
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