Drying Chamber for Lyophilization Systems | Specifications & Verification

Product Specifications

Technical details and manufacturing context for Drying Chamber

Definition

The Drying Chamber is a critical component of an Automated Pharmaceutical Lyophilization System. It is a precisely engineered, vacuum-tight enclosure designed to house pharmaceutical products during the primary and secondary drying phases of freeze-drying. The chamber provides a controlled environment where temperature, pressure, and shelf conditions are meticulously managed to facilitate the sublimation of ice and desorption of bound water from the product, resulting in a stable, dry final form suitable for long-term storage. Constructed from stainless steel 316L, the chamber ensures corrosion resistance and compliance with pharmaceutical hygiene standards. A tempered glass viewport allows visual inspection without compromising the vacuum seal. The chamber's internal volume ranges from 0.5 to 20 liters, with a shelf area from 1 to 50 square meters, accommodating various batch sizes. It operates under a maximum vacuum of 0.001 to 0.01 mbar, and the shelves can be controlled within a temperature range of -50 to 80 degrees Celsius, with uniformity of plus or minus 1 degree Celsius. The cooling and heating rates are adjustable between 0.5 to 2 and 0.5 to 3 degrees Celsius per minute, respectively, to optimize the drying cycle. The leak rate is maintained at or below 0.01 mbar·L/s, ensuring seal integrity. The chamber requires a three-phase power supply of 380 to 480 V AC (IEC 60038), with a rated power of 10 to 100 kW. The ingress protection rating is IP54 to IP65 (IEC 60529), and the weight ranges from 1000 to 15000 kg. These specifications are reference ranges; actual values must be confirmed with the manufacturer for specific models and applications.

Working Principle

The drying chamber operates under a high vacuum to lower the pressure below the triple point of water, enabling ice to sublimate directly from solid to vapor. Internal temperature-controlled shelves transfer heat to the product vials or trays, driving the sublimation process. The resulting water vapor is then transported out of the chamber to a condenser for capture. The chamber's vacuum-tight design and precise control of temperature and pressure are essential for efficient and uniform drying.

Common Materials

Stainless Steel (316L), Tempered Glass Viewport

Technical Parameters

Parameter	Typical range	Notes & selection driver
Chamber VolumeRequired	0.5–20 L	Total usable internal volume of the drying chamber
Maximum Operating VacuumRequired	0.001–0.01 mbar	The lowest pressure the chamber can maintain during operation
Shelf Temperature RangeRequired	-50–80 °C	Controllable temperature range of the internal heating/cooling shelves
Leak RateRequired	≤0.01 mbar·L/s	Maximum allowable rate of pressure increase indicating chamber seal integrity
Shelf Area	1–50 m²	Determines product load per batch.
Temperature Uniformity	±1 °C	Critical for consistent drying across shelves.
Cooling Rate	0.5–2 °C/min	Affects ice crystal formation and product quality.
Heating Rate	0.5–3 °C/min	Influences drying time and efficiency.
Power Supply	380–480 V AC	Three-phase, 50/60 Hz.IEC 60038
Rated Power	10–100 kW	Depends on chamber size and heating/cooling capacity.
Ingress Protection	IP54–IP65	Protects against dust and water jets.IEC 60529
Material	316L	Corrosion-resistant stainless steel for pharmaceutical use.ASTM A240
Weight	1000–15000 kg	Varies with size and configuration.

Ranges are indicative industry figures for RFQ preparation, not a supplier commitment. Confirm every value and standard with the legal manufacturer before ordering.

Components / BOM

Chamber Body
The chamber shell itself: encloses the process volume and carries the operating pressure and temperature.
Vacuum Seal Door
Provides airtight access to the chamber interior for loading/unloading product

Material: Stainless Steel with Silicone Gasket
Temperature-Controlled Shelves
Provide precise conductive heating/cooling to product containers to drive sublimation

Material: Stainless Steel with Internal Fluid Channels
Pressure Sensor Port Part
Interface for vacuum pressure measurement instrumentation

Material: Stainless Steel
Viewport Part
Allows visual inspection of the product and process inside the chamber without breaking vacuum

Material: Tempered Glass

Industry Taxonomies & Aliases

Commonly used trade names and technical identifiers for Drying Chamber.

Manufacturers of Drying Chamber

1 company lists this product among what they make. Company figures are quoted from each company's own website; every card states where the relationship came from.

NICETY Machinery

Shandong, CN

Also makes: Vibrating Screen, Screw Conveyor, Loading Hopper and 5 more

Listed on the company's own website · profile compiled by CNFX from public sources

View profile Send enquiry

Manufacturer listings support early research and capability understanding. They are not certification, ranking, or transaction guarantees.

Procurement Evaluation Criteria

A practical evidence checklist for RFQ preparation and supplier evaluation.

Technical documentation

Request current drawings, revision history, and a signed specification sheet.

Manufacturing capability

Verify equipment lists, process limits, capacity, and representative production evidence.

Inspection readiness

Confirm test methods, calibrated equipment, sampling plans, and traceable reports.

Supplier transparency

Check the legal entity, factory address, ownership, certifications, and direct contacts.

CNFX does not score or rank suppliers. Buyers must verify all claims and documents with the legal manufacturer before ordering.

Frequently Asked Questions

What is the typical volume range of a drying chamber?

The reference volume range is 0.5 to 20 liters, but the actual volume depends on the specific model and application. Always confirm with the manufacturer.

What materials are used in the drying chamber?

The chamber is typically made of stainless steel 316L, and it includes a tempered glass viewport. These materials are specified in the product data.

How is the leak rate of the chamber verified?

The leak rate is specified as ≤0.01 mbar·L/s. Verification should be performed according to the manufacturer's procedures and relevant standards.

What is the operating pressure range?

The operating pressure is 1.0 to 1.6 MPa. This is a reference range; confirm the exact value for your specific model.

Data Basis

Editorial classification, named public sources where available, and source-reviewed manufacturer records.

Preliminary Technical Classification

This page supports structured research, RFQ preparation, and supplier evaluation. It does not replace buyer-led supplier qualification, standards review, or technical approval.

Buyer enquiry

Request manufacturing insight for Drying Chamber

Ask for use case, specification boundaries, supplier type, and RFQ preparation information for this product.

Where it goes: Straight to the CNFX editorial desk, and to the manufacturer if this product is linked to a claimed profile. Nothing is broadcast to a supplier list.
Your details stay here: We do not sell or rent enquiry data, and we do not add you to a mailing list. Used only to answer this request.
No commission, no middleman: CNFX is a directory. We take no cut of any order and never negotiate on a supplier's behalf.
What we don't claim: A listing is not an endorsement. Qualify every supplier and verify every figure yourself before ordering.

pressure:	0.001 mbar to 1 atm
flow rate:	0.5 to 5 m³/h (gas)
temperature:	-50°C to +80°C
slurry concentration:	Up to 30% solids by volume

Drying Chamber

Product Specifications

Industry Taxonomies & Aliases

Industrial Ecosystem & Supply Chain Structure

Application Fit & Sizing Matrix

Reliability & Engineering Risk Analysis

Compliance & Manufacturing Standards