Connection Clamp: Temperature Range -20°C to 150°C

Q: What sterilization methods are compatible with this connection clamp?

The clamp is compatible with steam-in-place (SIP) up to 150°C, autoclaving at 121°C for 30 minutes, and chemical sterilization using validated agents like hydrogen peroxide or peracetic acid.

Q: How does the clamp maintain a sterile seal during pressure fluctuations?

It uses a spring-loaded or over-center locking mechanism that maintains constant sealing force, compensating for thermal expansion and pressure variations while preventing gasket creep or relaxation.

Q: What materials are used for gaskets in sterile applications?

PTFE (Teflon) or platinum-cured silicone gaskets that are USP Class VI compliant, non-shedding, and resistant to cleaning agents and sterilization cycles.

Component Specifications

Definition

A precision-engineered mechanical clamp designed to create and maintain sterile, hermetic connections between sterile product tanks and transfer lines or processing equipment in pharmaceutical, biotechnology, and aseptic manufacturing environments. It ensures contamination-free fluid transfer while withstanding sterilization cycles (SIP/CIP) and maintaining structural integrity under operational pressures.

Working Principle

Operates through a cam-locking or quick-connect mechanism that applies uniform circumferential pressure to seal gaskets or diaphragms between flanged connections, creating a sterile barrier. The clamp maintains constant sealing force through spring-loaded or over-center locking designs, preventing microbial ingress and maintaining aseptic conditions during product transfer.

Materials

316L stainless steel (ASTM A240/A276), electropolished to Ra ≤ 0.8 μm; PTFE or silicone gaskets (USP Class VI compliant); optional coatings: PTFE or ceramic for enhanced chemical resistance.

Technical Parameters

Parameter	Typical range	Notes & selection driver
Leak Rate	<1×10⁻⁹ mbar·L/s (helium leak test)
Size Range	1/2" to 4" (DN15 to DN100)
Sterilization	Autoclavable (121°C, 30 min), SIP compatible
Surface Finish	Electropolished, Ra ≤ 0.8 μm
Connection Type	Tri-clamp (Sanitary Clamp)
Pressure Rating	10 bar (145 psi) at 20°C
Temperature Range	-20°C to 150°C

Ranges are indicative industry figures for RFQ preparation, not a supplier commitment. Confirm every value and standard with the legal manufacturer before ordering.

Standards

ISO 2852, ASME BPE, DIN 32676, FDA 21 CFR Part 211

Parent Products

This component is used in the following industrial products

Sterile Product Tank Interface

Interface component connecting the sterile product tank to the aseptic filling machine's filling system

View Product Details

Engineering Analysis

Risks & Mitigation

Gasket failure leading to contamination
Improper installation causing leaks
Material incompatibility with process fluids
Fatigue failure from repeated sterilization cycles

FMEA Triads

Trigger: Gasket degradation from repeated sterilization
Failure: Loss of sterile seal, microbial contamination
Mitigation: Implement preventive maintenance schedule for gasket replacement; use dual-gasket designs with leak detection ports

Trigger: Incorrect clamp torque during installation
Failure: Uneven sealing pressure, potential leak paths
Mitigation: Use calibrated torque tools; implement installation training and verification procedures

Trigger: Corrosion from aggressive cleaning chemicals
Failure: Material degradation, particle generation
Mitigation: Specify 316L stainless steel with electropolishing; validate cleaning chemical compatibility

Industrial Ecosystem

Compatible With

Typical Suppliers & Equivalents

Compliance & Inspection

Tolerance

±0.1 mm on critical dimensions; surface roughness Ra ≤ 0.8 μm

Test Method

Helium leak testing per ASTM E499; pressure testing per ASME BPE; material certification per ASTM A240/A276; cleanability testing per ASTM E3218

Procurement Evaluation Criteria

A practical evidence checklist for RFQ preparation and supplier evaluation.

Technical documentation

Request current drawings, revision history, and a signed specification sheet.

Manufacturing capability

Verify equipment lists, process limits, capacity, and representative production evidence.

Inspection readiness

Confirm test methods, calibrated equipment, sampling plans, and traceable reports.

Supplier transparency

Check the legal entity, factory address, ownership, certifications, and direct contacts.

CNFX does not score or rank suppliers. Buyers must verify all claims and documents with the legal manufacturer before ordering.

Manufacturers of Connection Clamp

1 company lists this product among what they make. Company figures are quoted from each company's own website; every card states where the relationship came from.

XUZHOU DESHENG PETROL MACHINE CO., LTD.

Jiangsu, CN

Also makes: Fuel Nozzle, Manhole Cover, Flow Meter and 5 more

Listed on the company's own website · profile compiled by CNFX from public sources

View profile Send enquiry

Manufacturer listings support early research and capability understanding. They are not certification, ranking, or transaction guarantees.

Related Components

Mounting Interface

Precision mounting interface connecting punch tips to pharmaceutical tablet press machines for accurate tablet production.

Chrome Plating

Hard chrome plating is an electroplating process that deposits a layer of chromium onto metal surfaces to enhance wear resistance, corrosion protection, and reduce friction for hydraulic cylinder piston rods.

Upper Tool (Punch)

Upper Tool (Punch) is the active forming component in metal plate bending machines that applies precise downward force to create bends in sheet metal.

Main Frame

The main frame is the primary structural component of a hydraulic press, providing rigidity and stability to withstand high compressive forces during metal forming operations.

Frequently Asked Questions

What sterilization methods are compatible with this connection clamp?