Refrigeration System for Pharmaceutical Lyophilization

Product Specifications

Technical details and manufacturing context for Refrigeration System

Definition

The refrigeration system is a critical component of the Automated Pharmaceutical Lyophilization System. It removes heat from the product chamber and condenser to create and maintain the vacuum freeze-drying environment necessary for preserving sensitive pharmaceutical compounds. The system ensures precise temperature control during primary drying (sublimation) and secondary drying (desorption) phases. It operates on the vapor-compression cycle, circulating a refrigerant through a closed loop. The system compresses gaseous refrigerant, condenses it to liquid in a heat exchanger, expands it through an expansion valve to create cooling, and evaporates it in the evaporator to absorb heat from the lyophilization chamber and condenser. Key parameters include a cooling capacity of 15–60 kW, a temperature range of -40 to -85 °C, and a temperature control accuracy of ±0.5 °C. The system uses refrigerant R-404A and operates at pressures of 1.0–1.6 MPa. Power supply is 380–480 V AC, three-phase, 50/60 Hz (IEC 60038), with power consumption of 20–45 kW. Cooling rate ranges from 1–3 °C/min, and ambient temperature range is 5–40 °C. The enclosure protection rating is IP54–IP65 (IEC 60529). Refrigerant charge is 15–30 kg, noise level is ≤75 dB(A) (ISO 3744), weight is 800–1500 kg, and dimensions are 2000×1200×1800 mm. Materials include copper tubing, stainless steel components, and refrigerant. These values are directory reference ranges and must be verified with the legal manufacturer or supplier for the specific model and application.

Working Principle

The refrigeration system operates on the vapor-compression cycle. A refrigerant circulates through a closed loop: it is compressed as a gas, condensed to a liquid in a heat exchanger, expanded through an expansion valve to lower its temperature, and evaporated in the evaporator to absorb heat from the lyophilization chamber and condenser. This cycle removes heat from the product chamber and condenser, creating and maintaining the low-temperature environment required for freeze-drying. The system provides precise temperature control during primary and secondary drying phases.

Common Materials

Copper tubing, Stainless steel components, Refrigerant (R404A/R507)

Technical Parameters

Parameter	Typical range	Notes & selection driver
Cooling CapacityRequired	15–60 kW	Maximum heat removal capacity of the refrigeration system
Temperature RangeRequired	-40–-85 °C	Operating temperature range achievable by the system
Refrigerant TypeRequired	R-404A N/A	Type of refrigerant used in the system
Power Supply	380–480 V AC	Three-phase, 50/60 Hz; specify voltage and frequency.IEC 60038
Power Consumption	20–45 kW	Depends on cooling capacity and operating conditions.
Temperature Control Accuracy	±0.5 °C	Ensures uniform freeze-drying conditions.
Cooling Rate	1–3 °C/min	Faster rates may be required for certain products.
Ambient Temperature Range	5–40 °C	Operation outside this range may reduce performance.
Enclosure Protection Rating	IP54–IP65	Higher rating for washdown environments.IEC 60529
Refrigerant Charge	15–30 kg	Depends on system size and piping length.
Noise Level	≤75 dB(A)	Measured at 1 m distance; lower for cleanroom environments.ISO 3744
Weight	800–1500 kg	Skid-mounted unit; verify floor loading capacity.
Dimensions (L×W×H)	2000×1200×1800 mm	Typical footprint; confirm installation space.

Ranges are indicative industry figures for RFQ preparation, not a supplier commitment. Confirm every value and standard with the legal manufacturer before ordering.

Components / BOM

Compressor
Compresses refrigerant gas to increase pressure and temperature

Material: Cast iron or steel housing with copper windings
Condenser
Rejects heat from high-pressure refrigerant, converting it to liquid

Material: Copper tubes with aluminum fins
Expansion Valve
Controls refrigerant flow and pressure drop for cooling effect

Material: Brass or stainless steel
Evaporator
Absorbs heat from lyophilization chamber, evaporating refrigerant

Material: Stainless steel plates or coils
Refrigerant
The working fluid itself; its choice sets the lowest temperature the system can reach.

Industry Taxonomies & Aliases

Commonly used trade names and technical identifiers for Refrigeration System.

Applied To / Applications

This component is essential for the following industrial systems and equipment:

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Manufacturers of Refrigeration System

9 companies list this product among what they make. Company figures are quoted from each company's own website; every card states where the relationship came from.

HUDA Technology Pte. Ltd.

Yiyang, Hunan, CN

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